8CK5

VDR LBD complex with 25-nitro derivative of 1,25D3

8CK5 の概要

• エントリーDOI: 10.2210/pdb8ck5/pdb
• 分子名称: Vitamin D3 receptor A, Nuclear receptor coactivator 1, ACETATE ION, ... (5 entities in total)
• 機能のキーワード: complex, agonist, nuclear receptor, transcription
• 由来する生物種: Danio rerio (zebrafish); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 36341.42

構造登録者

Rochel, N. (登録日: 2023-02-14, 公開日: 2023-04-26, 最終更新日: 2024-06-19)

主引用文献

Gomez-Bouzo, U.,Belorusova, A.Y.,Rivadulla, M.L.,Santalla, H.,Verlinden, L.,Verstuyf, A.,Ferronato, M.J.,Curino, A.C.,Facchinetti, M.M.,Fall, Y.,Gomez, G.,Rochel, N.
Structural analysis and biological activities of C25-amino and C25-nitro vitamin D analogs.
Bioorg.Chem., 136:106528-106528, 2023

PubMed Abstract: Intense synthetic efforts have been directed towards the development of noncalcemic analogs of 1,25-dihydroxyvitamin D. We describe here the structural analysis and biological evaluation of two derivatives of 1,25-dihydroxyvitamin D with modifications limited to the replacement of the 25-hydroxyl group by a 25-amino or 25-nitro groups. Both compounds are agonists of the vitamin D receptor. They mediate biological effects similar to 1,25-dihydroxyvitamin D, the 25-amino derivative being the most potent one while being less calcemic than 1,25-dihydroxyvitamin D. The in vivo properties of the compounds make them of potential therapeutic value.

PubMed: 37054528
DOI: 10.1016/j.bioorg.2023.106528

実験手法

X-RAY DIFFRACTION (2.1 Å)