8CJV
Structure of bovine CD46 ectodomain (SCR 1-4)
Summary for 8CJV
| Entry DOI | 10.2210/pdb8cjv/pdb |
| Descriptor | Membrane cofactor protein, 2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total) |
| Functional Keywords | host cell receptor, immune system |
| Biological source | Bos taurus (cattle) |
| Total number of polymer chains | 2 |
| Total formula weight | 64500.62 |
| Authors | Aitkenhead, H.,Stuart, D.I.,El Omari, K. (deposition date: 2023-02-13, release date: 2023-07-12, Last modification date: 2024-11-06) |
| Primary citation | Aitkenhead, H.,Stuart, D.I.,El Omari, K. Structure of Bovine CD46 Ectodomain. Viruses, 15:-, 2023 Cited by PubMed Abstract: CD46, or membrane cofactor protein, is a type-one transmembrane protein from the complement regulatory protein family. Alongside its role in complement activation, CD46 is involved in many other processes, from T-cell activation to reproduction. It is also referred to as a pathogen magnet, because it is used as a receptor by multiple bacteria and viruses. Bovine CD46 (bovCD46) in particular is involved in bovine viral diarrhoea virus entry, an economically important disease in cattle industries. This study presents the X-ray crystallographic structure of the extracellular region of bovCD46, revealing a four-short-consensus-repeat (SCR) structure similar to that in human CD46. SCR1-3 are arranged linearly, while SCR 4 has a reduced interface angle, resulting in a hockey stick-like appearance. The structure also reveals the bovine viral diarrhoea virus interaction site in SCR1, which is likely to confer pestivirus specificity for their target host, CD46. Insights gained from the structural information on pestivirus receptors, such as CD46, could offer valuable guidance for future control strategies. PubMed: 37515111DOI: 10.3390/v15071424 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.84 Å) |
Structure validation
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