8CJV

Structure of bovine CD46 ectodomain (SCR 1-4)

8CJV の概要

• エントリーDOI: 10.2210/pdb8cjv/pdb
• 分子名称: Membrane cofactor protein, 2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total)
• 機能のキーワード: host cell receptor, immune system
• 由来する生物種: Bos taurus (cattle)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 64500.62

構造登録者

Aitkenhead, H.,Stuart, D.I.,El Omari, K. (登録日: 2023-02-13, 公開日: 2023-07-12, 最終更新日: 2024-11-06)

主引用文献

Aitkenhead, H.,Stuart, D.I.,El Omari, K.
Structure of Bovine CD46 Ectodomain.
Viruses, 15:-, 2023

PubMed Abstract: CD46, or membrane cofactor protein, is a type-one transmembrane protein from the complement regulatory protein family. Alongside its role in complement activation, CD46 is involved in many other processes, from T-cell activation to reproduction. It is also referred to as a pathogen magnet, because it is used as a receptor by multiple bacteria and viruses. Bovine CD46 (bovCD46) in particular is involved in bovine viral diarrhoea virus entry, an economically important disease in cattle industries. This study presents the X-ray crystallographic structure of the extracellular region of bovCD46, revealing a four-short-consensus-repeat (SCR) structure similar to that in human CD46. SCR1-3 are arranged linearly, while SCR 4 has a reduced interface angle, resulting in a hockey stick-like appearance. The structure also reveals the bovine viral diarrhoea virus interaction site in SCR1, which is likely to confer pestivirus specificity for their target host, CD46. Insights gained from the structural information on pestivirus receptors, such as CD46, could offer valuable guidance for future control strategies.

PubMed: 37515111
DOI: 10.3390/v15071424

実験手法

X-RAY DIFFRACTION (2.84 Å)