8CJM
Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-07-047
8CJM の概要
エントリーDOI | 10.2210/pdb8cjm/pdb |
分子名称 | Tryptophan 5-hydroxylase 1, FE (III) ION, 7-(cyclobutylmethyl)-3-ethyl-8-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)purine-2,6-dione, ... (4 entities in total) |
機能のキーワード | catalytic domain of human tryptophan hydroxylase 1 (tph1), inhibitor complex, metal binding protein |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 37862.91 |
構造登録者 | |
主引用文献 | Specker, E.,Wesolowski, R.,Schutz, A.,Matthes, S.,Mallow, K.,Wasinska-Kalwa, M.,Winkler, L.,Oder, A.,Alenina, N.,Pleimes, D.,von Kries, J.P.,Heinemann, U.,Bader, M.,Nazare, M. Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 66:14866-14896, 2023 Cited by PubMed: 37905925DOI: 10.1021/acs.jmedchem.3c01454 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.9 Å) |
構造検証レポート
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