8CGC
Structure of CSF1R in complex with a pyrollopyrimidine (compound 23)
Summary for 8CGC
| Entry DOI | 10.2210/pdb8cgc/pdb |
| Descriptor | Macrophage colony-stimulating factor 1 receptor, (2S)-2-hydroxybutanedioic acid, GLYCEROL, ... (5 entities in total) |
| Functional Keywords | kinase, csf1r, inhibitors, ligase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 39244.94 |
| Authors | Aarhus, T.I.,Bjornstad, F.,Wolowczyk, C.,Larsen, K.U.,Rognstad, L.,Leithaug, T.,Unger, A.,Habenberger, P.,Wolff, A.,Bjorkoy, G.,Pridans, C.,Eickhoff, J.,Klebl, B.,Hoff, B.H.,Sundby, E. (deposition date: 2023-02-03, release date: 2023-05-24, Last modification date: 2024-02-07) |
| Primary citation | Aarhus, T.I.,Bjornstad, F.,Wolowczyk, C.,Larsen, K.U.,Rognstad, L.,Leithaug, T.,Unger, A.,Habenberger, P.,Wolf, A.,Bjorkoy, G.,Pridans, C.,Eickhoff, J.,Klebl, B.,Hoff, B.H.,Sundby, E. Synthesis and Development of Highly Selective Pyrrolo[2,3- d ]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form. J.Med.Chem., 66:6959-6980, 2023 Cited by PubMed: 37191268DOI: 10.1021/acs.jmedchem.3c00428 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.925 Å) |
Structure validation
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