8CGC

Structure of CSF1R in complex with a pyrollopyrimidine (compound 23)

8CGC の概要

• エントリーDOI: 10.2210/pdb8cgc/pdb
• 分子名称: Macrophage colony-stimulating factor 1 receptor, (2S)-2-hydroxybutanedioic acid, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: kinase, csf1r, inhibitors, ligase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39244.94

構造登録者

Aarhus, T.I.,Bjornstad, F.,Wolowczyk, C.,Larsen, K.U.,Rognstad, L.,Leithaug, T.,Unger, A.,Habenberger, P.,Wolff, A.,Bjorkoy, G.,Pridans, C.,Eickhoff, J.,Klebl, B.,Hoff, B.H.,Sundby, E. (登録日: 2023-02-03, 公開日: 2023-05-24, 最終更新日: 2024-02-07)

• 主引用文献: Aarhus, T.I.,Bjornstad, F.,Wolowczyk, C.,Larsen, K.U.,Rognstad, L.,Leithaug, T.,Unger, A.,Habenberger, P.,Wolf, A.,Bjorkoy, G.,Pridans, C.,Eickhoff, J.,Klebl, B.,Hoff, B.H.,Sundby, E.; Synthesis and Development of Highly Selective Pyrrolo[2,3- d ]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form.; J.Med.Chem., 66:6959-6980, 2023; PubMed: 37191268; DOI: 10.1021/acs.jmedchem.3c00428

実験手法

X-RAY DIFFRACTION (1.925 Å)