8CDW

CRYSTAL STRUCTURE OF HUMAN HPK1 (MAP4K1) COMPLEX WITH 7-(1-methyl-1H-pyrazol-4-yl)-N-[4-(1-methylpiperidin-4-yl)phenyl]quinazolin-2-amine

8CDW の概要

• エントリーDOI: 10.2210/pdb8cdw/pdb
• 分子名称: Mitogen-activated protein kinase kinase kinase kinase 1, ~{N}-[4-(1-methylpiperidin-4-yl)phenyl]-7-(1-methylpyrazol-4-yl)quinazolin-2-amine (3 entities in total)
• 機能のキーワード: protein kinase, signaling protein, transferase, map4k1, hematopoietic progenitor kinase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69518.51

構造登録者

Musil, D.,Toure, M. (登録日: 2023-02-01, 公開日: 2023-08-16)

• 主引用文献: Toure, M.,Johnson, T.,Li, B.,Schmidt, R.,Ma, H.,Neagu, C.,Lopez, A.U.,Wang, Y.,Guler, S.,Xiao, Y.,Henkes, R.,Ho, K.,Zhang, S.,Chu, C.L.,Gundra, U.M.,Porichis, F.,Li, L.,Maurer, C.K.,Fang, Z.,Musil, D.,DiPoto, M.,Friis, E.,Jones, R.,Jones, C.,Cummings, J.,Chekler, E.,Tanzer, E.M.,Huck, B.,Sherer, B.; Discovery of quinazoline HPK1 inhibitors with high cellular potency.; Bioorg.Med.Chem., 92:117423-117423, 2023; PubMed: 37531921; DOI: 10.1016/j.bmc.2023.117423

実験手法

X-RAY DIFFRACTION (1.941 Å)