8CCX
Human SOD1 in complex with S-XL6 cross-linker
Summary for 8CCX
Entry DOI | 10.2210/pdb8ccx/pdb |
Descriptor | Superoxide dismutase [Cu-Zn], COPPER (II) ION, ZINC ION, ... (7 entities in total) |
Functional Keywords | sod1, amyotrophic lateral sclerosis, als, pharmacological chaperone, cross-linking, stabilization, oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 32698.75 |
Authors | Antonyuk, S.V.,Hossain, A.,Agar, J.N.,Hasnain, S.S. (deposition date: 2023-01-27, release date: 2023-12-13, Last modification date: 2024-02-07) |
Primary citation | Hossain, M.A.,Sarin, R.,Donnelly, D.P.,Miller, B.C.,Weiss, A.,McAlary, L.,Antonyuk, S.V.,Salisbury, J.P.,Amin, J.,Conway, J.B.,Watson, S.S.,Winters, J.N.,Xu, Y.,Alam, N.,Brahme, R.R.,Shahbazian, H.,Sivasankar, D.,Padmakumar, S.,Sattarova, A.,Ponmudiyan, A.C.,Gawde, T.,Verrill, D.E.,Yang, W.,Kannapadi, S.,Plant, L.D.,Auclair, J.R.,Makowski, L.,Petsko, G.A.,Ringe, D.,Agar, N.Y.R.,Greenblatt, D.J.,Ondrechen, M.J.,Chen, Y.,Yerbury, J.J.,Manetsch, R.,Hasnain, S.S.,Brown Jr., R.H.,Agar, J.N. Evaluating protein cross-linking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS. Plos Biol., 22:e3002462-e3002462, 2024 Cited by PubMed: 38289969DOI: 10.1371/journal.pbio.3002462 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.665 Å) |
Structure validation
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