8CC6
Mouse serotonin 5-HT3A receptor in complex with PZ-1922
Summary for 8CC6
Entry DOI | 10.2210/pdb8cc6/pdb |
EMDB information | 16555 |
Descriptor | 5-hydroxytryptamine receptor 3A, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | ion channel, receptor, plgic, transport protein |
Biological source | Mus musculus (house mouse) |
Total number of polymer chains | 5 |
Total formula weight | 325648.05 |
Authors | Lopez-Sanchez, U.,Nury, H. (deposition date: 2023-01-26, release date: 2023-10-11, Last modification date: 2023-11-22) |
Primary citation | Grychowska, K.,Lopez-Sanchez, U.,Vitalis, M.,Canet, G.,Satala, G.,Olejarz-Maciej, A.,Golebiowska, J.,Kurczab, R.,Pietrus, W.,Kubacka, M.,Moreau, C.,Walczak, M.,Blicharz-Futera, K.,Bento, O.,Bantreil, X.,Subra, G.,Bojarski, A.J.,Lamaty, F.,Becamel, C.,Zussy, C.,Chaumont-Dubel, S.,Popik, P.,Nury, H.,Marin, P.,Givalois, L.,Zajdel, P. Superiority of the Triple-Acting 5-HT 6 R/5-HT 3 R Antagonist and MAO-B Reversible Inhibitor PZ-1922 over 5-HT 6 R Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats. J.Med.Chem., 66:14928-14947, 2023 Cited by PubMed: 37797083DOI: 10.1021/acs.jmedchem.3c01482 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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