8CC2
Cathepsin B1 from Schistosoma mansoni in complex with gallinamide A
This is a non-PDB format compatible entry.
Summary for 8CC2
Entry DOI | 10.2210/pdb8cc2/pdb |
Related | 7JUJ |
Descriptor | Cathepsin B-like peptidase (C01 family), gallinamide A, bound form, SODIUM ION, ... (4 entities in total) |
Functional Keywords | cysteine protease, cathepsin b, smcb1, schistosoma mansoni, protease inhibitor peptidomimetic, gallinamide a, hydrolase |
Biological source | Schistosoma mansoni |
Total number of polymer chains | 1 |
Total formula weight | 29125.03 |
Authors | Rubesova, P.,Brynda, J.,Mares, M.,Gerwick, W.H. (deposition date: 2023-01-26, release date: 2024-02-07, Last modification date: 2024-08-07) |
Primary citation | Spiwokova, P.,Horn, M.,Fanfrlik, J.,Jilkova, A.,Fajtova, P.,Leontovyc, A.,Houstecka, R.,Bielikova, L.,Brynda, J.,Chanova, M.,Mertlikova-Kaiserova, H.,Caro-Diaz, E.J.E.,Almaliti, J.,El-Sakkary, N.,Gerwick, W.H.,Caffrey, C.R.,Mares, M. Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhibition of the Cathepsin B1 Protease Target and Binding Mode Analysis. Acs Infect Dis., 10:1935-1948, 2024 Cited by PubMed: 38757505DOI: 10.1021/acsinfecdis.3c00589 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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