8CBR
HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor BDM-2
Summary for 8CBR
Entry DOI | 10.2210/pdb8cbr/pdb |
Descriptor | Integrase, (2S)-2-[3-cyclopropyl-2-(3,4-dihydro-2H-chromen-6-yl)-6-methyl-phenyl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | integrase, hiv, allini, allosteric inhibitor, inhibitor, retrovirus, inlai, ncini, mini, ledgin, mutabilis, bdm-2, viral protein |
Biological source | Human immunodeficiency virus 1 More |
Total number of polymer chains | 4 |
Total formula weight | 105360.17 |
Authors | Singer, M.R.,Pye, V.E.,Yu, Z.,Cherepanov, P. (deposition date: 2023-01-25, release date: 2023-06-07, Last modification date: 2024-06-19) |
Primary citation | Bonnard, D.,Le Rouzic, E.,Singer, M.R.,Yu, Z.,Le Strat, F.,Batisse, C.,Batisse, J.,Amadori, C.,Chasset, S.,Pye, V.E.,Emiliani, S.,Ledoussal, B.,Ruff, M.,Moreau, F.,Cherepanov, P.,Benarous, R. Biological and Structural Analyses of New Potent Allosteric Inhibitors of HIV-1 Integrase. Antimicrob.Agents Chemother., 67:e0046223-e0046223, 2023 Cited by PubMed: 37310224DOI: 10.1128/aac.00462-23 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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