8CAX

Structure of Tau filaments Type II from Subacute Sclerosing Panencephalitis

8CAX の概要

• エントリーDOI: 10.2210/pdb8cax/pdb
• 関連するPDBエントリー: 8CAQ
• EMDBエントリー: 16535
• 分子名称: Microtubule-associated protein tau (1 entity in total)
• 機能のキーワード: tau filament, sspe, neurodegenerative disease, protein fibril
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 275519.23

構造登録者

Qi, C.,Hasegawa, M.,Takao, M.,Sakai, M.,Akagi, M.,Iwasaki, Y.,Yoshida, M.,Scheres, S.H.W.,Goedert, M. (登録日: 2023-01-24, 公開日: 2023-11-08)

主引用文献

Qi, C.,Hasegawa, M.,Takao, M.,Sakai, M.,Sasaki, M.,Mizutani, M.,Akagi, A.,Iwasaki, Y.,Miyahara, H.,Yoshida, M.,Scheres, S.H.W.,Goedert, M.
Identical tau filaments in subacute sclerosing panencephalitis and chronic traumatic encephalopathy.
Acta Neuropathol Commun, 11:74-74, 2023

PubMed Abstract: Subacute sclerosing panencephalitis (SSPE) occurs in some individuals after measles infection, following a symptom-free period of several years. It resembles chronic traumatic encephalopathy (CTE), which happens after repetitive head impacts or exposure to blast waves, following a symptom-free period. As in CTE, the neurofibrillary changes of SSPE are concentrated in superficial cortical layers. Here we used electron cryo-microscopy (cryo-EM) of tau filaments from two cases of SSPE to show that the tau folds of SSPE and CTE are identical. Two types of filaments were each made of two identical protofilaments with an extra density in the β-helix region. Like in CTE, the vast majority of tau filaments were Type I, with a minority of Type II filaments. These findings suggest that the CTE tau fold can be caused by different environmental insults, which may be linked by inflammatory changes.

PubMed: 37143123
DOI: 10.1186/s40478-023-01565-2

実験手法

ELECTRON MICROSCOPY (3.7 Å)