8CAP

Crystal structure of dehydrogenase domain of Cylindrospermum stagnale NADPH-Oxidase 5 (NOX5) in complex with CB28

8CAP の概要

• エントリーDOI: 10.2210/pdb8cap/pdb
• 分子名称: Putative ferric reductase, FLAVIN-ADENINE DINUCLEOTIDE, [4-[[(4~{E})-4-(furan-2-ylmethylidene)-2,3-dihydro-1~{H}-acridin-9-yl]carbonyl]piperazin-1-yl]-pyridin-2-yl-methanone (3 entities in total)
• 機能のキーワード: ros, inhibitor, redox biology, oxidoreductase
• 由来する生物種: Cylindrospermum stagnale
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 133980.03

構造登録者

Reis, J.,Mattevi, A. (登録日: 2023-01-24, 公開日: 2023-09-27, 最終更新日: 2024-04-10)

• 主引用文献: Reis, J.,Gorgulla, C.,Massari, M.,Marchese, S.,Valente, S.,Noce, B.,Basile, L.,Torner, R.,Cox 3rd, H.,Viennet, T.,Yang, M.H.,Ronan, M.M.,Rees, M.G.,Roth, J.A.,Capasso, L.,Nebbioso, A.,Altucci, L.,Mai, A.,Arthanari, H.,Mattevi, A.; Targeting ROS production through inhibition of NADPH oxidases.; Nat.Chem.Biol., 19:1540-1550, 2023; PubMed: 37884805; DOI: 10.1038/s41589-023-01457-5

実験手法

X-RAY DIFFRACTION (3 Å)