8CA0

Macrophage inhibitory factor (MIF) in complex with small molecule PAV174

8CA0 の概要

• エントリーDOI: 10.2210/pdb8ca0/pdb
• NMR情報: BMRB: 34783
• 分子名称: Macrophage migration inhibitory factor, 1-ethyl-9-methyl-3,7-dipyrrolidin-1-yl-phenothiazine (2 entities in total)
• 機能のキーワード: mif, oxmif, herpes, alzheimer's disease, protein binding
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 37444.73

構造登録者

Mueller, A.,Torres, F.,Roland, R.,Korth, C. (登録日: 2023-01-24, 公開日: 2024-02-07)

• 主引用文献: Mueller-Schiffmann, A.,Torres, F.,Kitaygorodskyy, A.,Ramani, A.,Alatza, A.,Tschirner, S.,Prikulis, I.,Yu, S.,Dey, D.,Mallesh, S.,Prasad, D.,Solas, D.,Bader, V.,Rozemuller, A.,Wray, S.,Gopalakrishnan, J.,Riek, R.,Lingappa, V.R.,Korth, C.; Oxidized MIF is a drug target at the molecular intersection between immune activation and tau cellular pathology; To Be Published,

実験手法

SOLUTION NMR