8C9W

Crystal structure of the adenosine A2A receptor (construct A2A-PSB2-bRIL) complexed with Etrumadenant at the orthosteric pocket

8C9W の概要

• エントリーDOI: 10.2210/pdb8c9w/pdb
• 分子名称: Adenosine receptor A2a,Soluble cytochrome b562, 3-[2-azanyl-6-[1-[[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]methyl]-1,2,3-triazol-4-yl]pyrimidin-4-yl]-2-methyl-benzenecarbonitrile, CHOLESTEROL, ... (8 entities in total)
• 機能のキーワード: gpcr, bril, antagonist, purinergic signaling, cancer immunotherapy, membrane protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 52331.55

構造登録者

Strater, N.,Claff, T.,Schlegel, J.G.,Voss, J.H.,Vaassen, V.,Muller, C.E. (登録日: 2023-01-23, 公開日: 2023-07-12, 最終更新日: 2024-01-31)

• 主引用文献: Claff, T.,Schlegel, J.G.,Voss, J.H.,Vaassen, V.J.,Weisse, R.H.,Cheng, R.K.Y.,Markovic-Mueller, S.,Bucher, D.,Strater, N.,Muller, C.E.; Crystal structure of adenosine A 2A receptor in complex with clinical candidate Etrumadenant reveals unprecedented antagonist interaction.; Commun Chem, 6:106-106, 2023; PubMed: 37264098; DOI: 10.1038/s42004-023-00894-6

実験手法

X-RAY DIFFRACTION (2.114 Å)