8C8W

Priestia megaterium mupirocin hyper-resistant HIGH motif mutant of type 2 isoleucyl-tRNA synthetase complexed with an isoleucyl-adenylate analogue

8C8W の概要

• エントリーDOI: 10.2210/pdb8c8w/pdb
• 分子名称: Isoleucine--tRNA ligase, N-[ISOLEUCINYL]-N'-[ADENOSYL]-DIAMINOSUFONE, D(-)-TARTARIC ACID, ... (5 entities in total)
• 機能のキーワード: antibiotic, mupirocin-resistant, ilers2, rna-binding protein, c-terminal domain, rna binding protein
• 由来する生物種: Priestia megaterium
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 119053.50

構造登録者

Brkic, A.,Leibundgut, M.,Jablonska, J.,Zanki, V.,Car, Z.,Petrovic Perokovic, V.,Ban, N.,Gruic-Sovulj, I. (登録日: 2023-01-21, 公開日: 2023-08-16, 最終更新日: 2024-03-27)

• 主引用文献: Brkic, A.,Leibundgut, M.,Jablonska, J.,Zanki, V.,Car, Z.,Petrovic Perokovic, V.,Marsavelski, A.,Ban, N.,Gruic-Sovulj, I.; Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif.; Nat Commun, 14:5498-5498, 2023; PubMed: 37679387; DOI: 10.1038/s41467-023-41244-3

実験手法

X-RAY DIFFRACTION (2.29 Å)