8C7R

Crystal structure of rat autotaxin and compound MEY-003

8C7R の概要

• エントリーDOI: 10.2210/pdb8c7r/pdb
• 分子名称: Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5,7-bis(oxidanyl)-2-(1-pentylindol-3-yl)chromen-4-one, ... (8 entities in total)
• 機能のキーワード: inhibitor, co-crystal, ectonucleotide pyrophosphatase/phosphodiesterase (enpp), hydrolase
• 由来する生物種: Rattus norvegicus (Norway rat)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 100735.30

構造登録者

Eymery, M.C.,McCarthy, A.A. (登録日: 2023-01-17, 公開日: 2023-11-22, 最終更新日: 2023-11-29)

• 主引用文献: Eymery, M.C.,Nguyen, K.A.,Basu, S.,Hausmann, J.,Tran-Nguyen, V.K.,Seidel, H.P.,Gutierrez, L.,Boumendjel, A.,McCarthy, A.A.; Discovery of potent chromone-based autotaxin inhibitors inspired by cannabinoids.; Eur.J.Med.Chem., 263:115944-115944, 2023; PubMed: 37976710; DOI: 10.1016/j.ejmech.2023.115944

実験手法

X-RAY DIFFRACTION (2.53 Å)