8C79

Crystal structure of Leishmania donovani 6-Phosphogluconate Dehydrogenase complexed with NADPH

8C79 の概要

• エントリーDOI: 10.2210/pdb8c79/pdb
• 分子名称: 6-phosphogluconate dehydrogenase, decarboxylating, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: leishmania donovani, trypanosoma, pentose phosphate pathway, 6-phosphogluconate dehydrogenase, oxidoreductase, antioxidant defense, drug target
• 由来する生物種: Leishmania donovani
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 105416.71

構造登録者

Fritz-Wolf, K.,Berneburg, I.,Rahlfs, S.,Becker, K. (登録日: 2023-01-13, 公開日: 2023-05-24, 最終更新日: 2024-02-07)

• 主引用文献: Berneburg, I.,Stumpf, M.,Velten, A.S.,Rahlfs, S.,Przyborski, J.,Becker, K.,Fritz-Wolf, K.; Structure of Leishmania donovani 6-Phosphogluconate Dehydrogenase and Inhibition by Phosphine Gold(I) Complexes: A Potential Approach to Leishmaniasis Treatment.; Int J Mol Sci, 24:-, 2023; PubMed: 37239962; DOI: 10.3390/ijms24108615

実験手法

X-RAY DIFFRACTION (3.1 Å)