8C49

Crystal structure of pyrrolysyl-tRNA synthetase from Methanomethylophilus alvus engineered for 3-Methyl-L-histidine, bound to AMPPNP

8C49 の概要

• エントリーDOI: 10.2210/pdb8c49/pdb
• 分子名称: Pyrrolysyl-tRNA synthetase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, DI(HYDROXYETHYL)ETHER, ... (7 entities in total)
• 機能のキーワード: pyrrolysyl-trna synthetase, genetic code expansion, engineered translation components, methanomethylophilus alvus, ligase
• 由来する生物種: Candidatus Methanomethylophilus alvus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 66439.65

構造登録者

Hardy, F.J.,Levy, C.W. (登録日: 2023-01-03, 公開日: 2023-07-19, 最終更新日: 2024-02-07)

• 主引用文献: Taylor, C.J.,Hardy, F.J.,Burke, A.J.,Bednar, R.M.,Mehl, R.A.,Green, A.P.,Lovelock, S.L.; Engineering mutually orthogonal PylRS/tRNA pairs for dual encoding of functional histidine analogues.; Protein Sci., 32:e4640-e4640, 2023; PubMed: 37051694; DOI: 10.1002/pro.4640

実験手法

X-RAY DIFFRACTION (1.82 Å)