8C2Z
Crystal structure of DYRK1B in complex with AZ191
Summary for 8C2Z
Entry DOI | 10.2210/pdb8c2z/pdb |
Descriptor | Dual specificity tyrosine-phosphorylation-regulated kinase 1B, N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine, MANGANESE (II) ION, ... (4 entities in total) |
Functional Keywords | kinase, diabetes, kinase inhibitor, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 43498.45 |
Authors | Grygier, P.,Pustelny, K.,Dubin, G.,Czarna, A. (deposition date: 2022-12-23, release date: 2024-01-17) |
Primary citation | Grygier, P.,Pustelny, K.,Dubin, G.,Czarna, A. Structural perspective on the design of selective DYRK1B inhibitors To Be Published, |
Experimental method |
Structure validation
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