8C1D

Aurora A kinase in complex with TPX2-inhibitor 9

8C1D の概要

• エントリーDOI: 10.2210/pdb8c1d/pdb
• 分子名称: Aurora kinase A, 4-(4-chlorophenyl)-7-methyl-1~{H}-indole-6-carboxylic acid, ADENOSINE-5'-DIPHOSPHATE, ... (9 entities in total)
• 機能のキーワード: protein-ligand complex, kinase, protein-protein interaction inhibitor, cell cycle
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32475.73

構造登録者

Fischer, G.,Rocaboy, M.,Blaszczyk, B.,Moschetti, T.,Wang, X.,Scott, D.E.,Coyne, A.G.,Dagostin, C.,Rooney, T.,Bayly, A.,Feng, J.,Asteian, A.,Alcaide-Lopez, A.,Stockwell, S.,Skidmore, J.,Venkitaraman, A.R.,Abell, C.,Blundell, T.L.,Hyvonen, M. (登録日: 2022-12-20, 公開日: 2024-01-10)

• 主引用文献: Stockwell, S.,Scott, D.,Fischer, G.,Guarino Almeida, E.,Rooney, T.,Feng, J.,Moschetti, T.,Dagostin, C.,Alcaide-Lopez, A.,Rocaboy, M.,Srinivasan, R.,Asteian, A.,Alza, E.,Blaszczyk, B.,Wang, X.,Rossmann, M.,Perrior, T.,Blundell, T.L.,Spring, D.R.,McKenzie, G.,Abell, C.,Skidmore, J.,Venkitaraman, A.,Hyvonen, M.; Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agent; To Be Published,

実験手法

X-RAY DIFFRACTION (2.115 Å)