8C19

SARS-CoV-2 NSP3 macrodomain in complex with 1-methyl-4-[5-(morpholin-4-ylcarbonyl)-2-furyl]-1H-pyrrolo[2,3-b]pyridine

Summary for 8C19

• Entry DOI: 10.2210/pdb8c19/pdb
• Descriptor: Non-structural protein 3, 1,2-ETHANEDIOL, [5-(1-methylpyrrolo[2,3-b]pyridin-4-yl)furan-2-yl]-morpholin-4-yl-methanone, ... (4 entities in total)
• Functional Keywords: macrodomain, adp-ribose, sars-cov-2, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2
• Total number of polymer chains: 2
• Total formula weight: 36979.21

Authors

Schuller, M.,Ahel, I. (deposition date: 2022-12-20, release date: 2023-03-08)

• Primary citation: Schuller, M.,Zarganes-Tzitzikas, T.,Bennett, J.,De Cesco, S.,Fearon, D.,von Delft, F.,Fedorov, O.,Brennan, P.E.,Ahel, I.; Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors.; Pathogens, 12:-, 2023; PubMed: 36839595; DOI: 10.3390/pathogens12020324

Experimental method

X-RAY DIFFRACTION (1.95 Å)