8C0R

Crystal structure of human carbonic anhydrase II in complex with a coumarin derivative.

8C0R の概要

• エントリーDOI: 10.2210/pdb8c0r/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, bis(fluoranyl)-(4-methyl-2-oxidanylidene-chromen-7-yl)methanesulfonamide, ... (4 entities in total)
• 機能のキーワード: difluoromethanesulfonamide, protein-inhibitor complex, carbonic anhydrase ii, coumarin, lyase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29643.73

構造登録者

Alterio, V.,De Simone, G.,Esposito, D. (登録日: 2022-12-19, 公開日: 2023-03-08, 最終更新日: 2024-02-14)

• 主引用文献: Langella, E.,Esposito, D.,Monti, S.M.,Supuran, C.T.,De Simone, G.,Alterio, V.; A Combined in Silico and Structural Study Opens New Perspectives on Aliphatic Sulfonamides, a Still Poorly Investigated Class of CA Inhibitors.; Biology (Basel), 12:-, 2023; PubMed: 36829558; DOI: 10.3390/biology12020281

実験手法

X-RAY DIFFRACTION (1.56 Å)