8C0P

Crystal structure of S. aureus BlaR1 sensor domain in complex with a boronate inhibitor

Summary for 8C0P

Entry DOI	10.2210/pdb8c0p/pdb
Descriptor	Regulatory protein BlaR1, [1-[[2,4-bis(trifluoromethyl)phenyl]methyl]benzimidazol-2-yl]sulfanylmethyl-$l^{3}-oxidanyl-bis(oxidanyl)boron (3 entities in total)
Functional Keywords	antibiotic resistance, beta-lactam sensor of staphylococcus aureus, mrsa, signaling protein
Biological source	Staphylococcus aureus More
Total number of polymer chains	2
Total formula weight	60443.21
Authors	Miguel-Ruano, V.,Jimenez-Faraco, E.,Hermoso, J.A. (deposition date: 2022-12-19, release date: 2024-07-10, Last modification date: 2024-09-04)
Primary citation	Nguyen, V.T.,Birhanu, B.T.,Miguel-Ruano, V.,Kim, C.,Batuecas, M.,Yang, J.,El-Araby, A.M.,Jimenez-Faraco, E.,Schroeder, V.A.,Alba, A.,Rana, N.,Sader, S.,Thomas, C.A.,Feltzer, R.,Lee, M.,Fisher, J.F.,Hermoso, J.A.,Chang, M.,Mobashery, S. Restoring susceptibility to beta-lactam antibiotics in methicillin-resistant Staphylococcus aureus. Nat.Chem.Biol., 2024 Cited by PubMed: 39060390 DOI: 10.1038/s41589-024-01688-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.97 Å)

Structure validation