8C0C

X-ray crystal structure of PPAR gamma ligand binding domain in complex with CZ46

Summary for 8C0C

Entry DOI	10.2210/pdb8c0c/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, (2~{R})-2-[4-(naphthalen-1-ylmethoxy)phenyl]-4-oxidanyl-3-phenyl-2~{H}-furan-5-one (3 entities in total)
Functional Keywords	ppar, nuclear receptor, transcription, nuclear protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	69247.91
Authors	Capelli, D.,Montanari, R.,Pochetti, G.,Villa, S.,Meneghetti, F. (deposition date: 2022-12-16, release date: 2023-04-26, Last modification date: 2024-06-19)
Primary citation	Capelli, D.,Cazzaniga, G.,Mori, M.,Laghezza, A.,Loiodice, F.,Quaglia, M.,Negro, E.,Meneghetti, F.,Villa, S.,Montanari, R. Biological Screening and Crystallographic Studies of Hydroxy gamma-Lactone Derivatives to Investigate PPAR gamma Phosphorylation Inhibition. Biomolecules, 13:-, 2023 Cited by PubMed: 37189440 DOI: 10.3390/biom13040694 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation