8C0C

X-ray crystal structure of PPAR gamma ligand binding domain in complex with CZ46

8C0C の概要

• エントリーDOI: 10.2210/pdb8c0c/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, (2~{R})-2-[4-(naphthalen-1-ylmethoxy)phenyl]-4-oxidanyl-3-phenyl-2~{H}-furan-5-one (3 entities in total)
• 機能のキーワード: ppar, nuclear receptor, transcription, nuclear protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69247.91

構造登録者

Capelli, D.,Montanari, R.,Pochetti, G.,Villa, S.,Meneghetti, F. (登録日: 2022-12-16, 公開日: 2023-04-26, 最終更新日: 2024-06-19)

• 主引用文献: Capelli, D.,Cazzaniga, G.,Mori, M.,Laghezza, A.,Loiodice, F.,Quaglia, M.,Negro, E.,Meneghetti, F.,Villa, S.,Montanari, R.; Biological Screening and Crystallographic Studies of Hydroxy gamma-Lactone Derivatives to Investigate PPAR gamma Phosphorylation Inhibition.; Biomolecules, 13:-, 2023; PubMed: 37189440; DOI: 10.3390/biom13040694

実験手法

X-RAY DIFFRACTION (2.2 Å)