8C09
Crystal structure of JAK2 JH2-I559F
Summary for 8C09
Entry DOI | 10.2210/pdb8c09/pdb |
Descriptor | Tyrosine-protein kinase JAK2 (2 entities in total) |
Functional Keywords | janus kinase, pseudokinase, jak2, jh2, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 33154.98 |
Authors | Haikarainen, T.,Silvennoinen, O. (deposition date: 2022-12-16, release date: 2023-12-27, Last modification date: 2024-03-20) |
Primary citation | Abraham, B.G.,Haikarainen, T.,Vuorio, J.,Girych, M.,Virtanen, A.T.,Kurttila, A.,Karathanasis, C.,Heilemann, M.,Sharma, V.,Vattulainen, I.,Silvennoinen, O. Molecular basis of JAK2 activation in erythropoietin receptor and pathogenic JAK2 signaling. Sci Adv, 10:eadl2097-eadl2097, 2024 Cited by PubMed: 38457493DOI: 10.1126/sciadv.adl2097 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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