8C08

Crystal structure of JAK2 JH2-K539L

Summary for 8C08

Entry DOI	10.2210/pdb8c08/pdb
Descriptor	Tyrosine-protein kinase JAK2, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	janus kinase, pseudokinase, jak2, jh2, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	67364.94
Authors	Haikarainen, T. (deposition date: 2022-12-16, release date: 2023-12-27, Last modification date: 2024-03-20)
Primary citation	Abraham, B.G.,Haikarainen, T.,Vuorio, J.,Girych, M.,Virtanen, A.T.,Kurttila, A.,Karathanasis, C.,Heilemann, M.,Sharma, V.,Vattulainen, I.,Silvennoinen, O. Molecular basis of JAK2 activation in erythropoietin receptor and pathogenic JAK2 signaling. Sci Adv, 10:eadl2097-eadl2097, 2024 Cited by PubMed: 38457493 DOI: 10.1126/sciadv.adl2097 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation