8BZX

1-deoxy-D-xylulose 5-phosphate synthase from Klebsiella pneumoniae (kpDXPS),co-crystal with thiamine monophosphate analog

8BZX の概要

• エントリーDOI: 10.2210/pdb8bzx/pdb
• 分子名称: 1-deoxy-D-xylulose-5-phosphate synthase, 2-[4-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-3-methyl-5-propanoyl-thiophen-2-yl]ethyl dihydrogen phosphate, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: 1-deoxy-d-xylulose 5-phosphate synthase, klebsiella pneumoniae, thiamine monophosphate, transferase
• 由来する生物種: Klebsiella pneumoniae; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 127379.97

構造登録者

Hamid, R. (登録日: 2022-12-15, 公開日: 2023-06-14, 最終更新日: 2024-06-19)

• 主引用文献: Chan, A.H.Y.,Ho, T.C.S.,Irfan, R.,Hamid, R.A.A.,Rudge, E.S.,Iqbal, A.,Turner, A.,Hirsch, A.K.H.,Leeper, F.J.; Design of thiamine analogues for inhibition of thiamine diphosphate (ThDP)-dependent enzymes: Systematic investigation through Scaffold-Hopping and C2-Functionalisation.; Bioorg.Chem., 138:106602-106602, 2023; PubMed: 37201323; DOI: 10.1016/j.bioorg.2023.106602

実験手法

X-RAY DIFFRACTION (2.05 Å)