8BZI
Human MST3 (STK24) kinase in complex with inhibitor MR39
Summary for 8BZI
Entry DOI | 10.2210/pdb8bzi/pdb |
Descriptor | Serine/threonine-protein kinase 24, 8-(4-azanylbutyl)-6-[2,5-bis(fluoranyl)-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | selective kinase inhibitors, structure-based drug design, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 35196.34 |
Authors | Balourdas, D.I.,Rak, M.,Tesch, R.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) (deposition date: 2022-12-14, release date: 2023-01-18, Last modification date: 2024-02-07) |
Primary citation | Rak, M.,Tesch, R.,Berger, L.M.,Shevchenko, E.,Raab, M.,Tjaden, A.,Zhubi, R.,Balourdas, D.I.,Joerger, A.C.,Poso, A.,Kramer, A.,Elson, L.,Lucic, A.,Kronenberger, T.,Hanke, T.,Strebhardt, K.,Sanhaji, M.,Knapp, S. Shifting the selectivity of pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors towards the salt-inducible kinase (SIK) subfamily. Eur.J.Med.Chem., 254:115347-115347, 2023 Cited by PubMed: 37094449DOI: 10.1016/j.ejmech.2023.115347 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.72 Å) |
Structure validation
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