8BZI

Human MST3 (STK24) kinase in complex with inhibitor MR39

8BZI の概要

• エントリーDOI: 10.2210/pdb8bzi/pdb
• 分子名称: Serine/threonine-protein kinase 24, 8-(4-azanylbutyl)-6-[2,5-bis(fluoranyl)-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: selective kinase inhibitors, structure-based drug design, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35196.34

構造登録者

Balourdas, D.I.,Rak, M.,Tesch, R.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) (登録日: 2022-12-14, 公開日: 2023-01-18, 最終更新日: 2024-02-07)

• 主引用文献: Rak, M.,Tesch, R.,Berger, L.M.,Shevchenko, E.,Raab, M.,Tjaden, A.,Zhubi, R.,Balourdas, D.I.,Joerger, A.C.,Poso, A.,Kramer, A.,Elson, L.,Lucic, A.,Kronenberger, T.,Hanke, T.,Strebhardt, K.,Sanhaji, M.,Knapp, S.; Shifting the selectivity of pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors towards the salt-inducible kinase (SIK) subfamily.; Eur.J.Med.Chem., 254:115347-115347, 2023; PubMed: 37094449; DOI: 10.1016/j.ejmech.2023.115347

実験手法

X-RAY DIFFRACTION (1.72 Å)