8BWZ

fragment-linked stabilizer for ERa - 14-3-3 interaction (1074393)

Summary for 8BWZ

Entry DOI	10.2210/pdb8bwz/pdb
Descriptor	14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-(4-ethanoylphenoxy)-2-methyl-propanamide, ... (4 entities in total)
Functional Keywords	14-3-3, era, fragment linking, stabilization, structural protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	27594.02
Authors	Visser, E.J.,Vandenboorn, E.M.F.,Ottmann, C. (deposition date: 2022-12-07, release date: 2023-08-02, Last modification date: 2023-11-15)
Primary citation	Visser, E.J.,Jaishankar, P.,Sijbesma, E.,Pennings, M.A.M.,Vandenboorn, E.M.F.,Guillory, X.,Neitz, R.J.,Morrow, J.,Dutta, S.,Renslo, A.R.,Brunsveld, L.,Arkin, M.R.,Ottmann, C. From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62:e202308004-e202308004, 2023 Cited by PubMed: 37455289 DOI: 10.1002/anie.202308004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation