8BWQ

Cryo-EM structure of nanodisc-reconstituted wildtype human MRP4 (in complex with topotecan)

Summary for 8BWQ

Entry DOI	10.2210/pdb8bwq/pdb
Related	8BJF 8BWO 8BWP
EMDB information	16088 16292 16293 16294
Descriptor	ATP-binding cassette sub-family C member 4, (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE (2 entities in total)
Functional Keywords	abc transporter, abcc4, mrp4, topotecan bound, translocase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	150115.37
Authors	Raj, I.,Bloch, M.,Pape, T.H.,Taylor, N.M.I. (deposition date: 2022-12-07, release date: 2023-08-30, Last modification date: 2023-11-15)
Primary citation	Bloch, M.,Raj, I.,Pape, T.,Taylor, N.M.I. Structural and mechanistic basis of substrate transport by the multidrug transporter MRP4. Structure, 31:1407-1418.e6, 2023 Cited by PubMed: 37683641 DOI: 10.1016/j.str.2023.08.014 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.9 Å)

Structure validation