8BTV
Structure of D179N BlaC from Mycobacterium tuberculosis bound to the trans-enamine adduct of sulbactam
Summary for 8BTV
Entry DOI | 10.2210/pdb8btv/pdb |
Descriptor | Beta-lactamase, TRANS-ENAMINE INTERMEDIATE OF SULBACTAM, GLYCEROL, ... (5 entities in total) |
Functional Keywords | hydrolase |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Total number of polymer chains | 1 |
Total formula weight | 28938.18 |
Authors | Chikunova, A.,Bruenle, S.,Ubbink, M. (deposition date: 2022-12-02, release date: 2023-07-05, Last modification date: 2023-11-22) |
Primary citation | van Alen, I.,Chikunova, A.,van Zanten, D.B.,de Block, A.A.,Timmer, M.,Brunle, S.,Ubbink, M. Asp179 in the class A beta-lactamase from Mycobacterium tuberculosis is a conserved yet not essential residue due to epistasis. Febs J., 290:4933-4949, 2023 Cited by PubMed: 37335937DOI: 10.1111/febs.16892 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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