8BTO

Helical structure of BcThsA in complex with 1''-3'gcADPR

Summary for 8BTO

• Entry DOI: 10.2210/pdb8bto/pdb
• Related: 8BTN 8BTP
• EMDB information: 16233
• Descriptor: NAD(+) hydrolase ThsA, (2R,3R,3aS,5S,6R,7S,8R,11R,13S,15aR)-2-(6-amino-9H-purin-9-yl)-3,6,7,11,13-pentahydroxyoctahydro-2H,5H,11H,13H-5,8-epoxy-11lambda~5~,13lambda~5~-furo[2,3-g][1,3,5,9,2,4]tetraoxadiphosphacyclotetradecine-11,13-dione, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (3 entities in total)
• Functional Keywords: thoeris, sir2 domain, slog domain, 3'cadpr, hydrolase
• Biological source: Bacillus cereus MSX-D12
• Total number of polymer chains: 12
• Total formula weight: 679469.65

Authors

Tamulaitiene, G.,Sasnauskas, G.,Sabonis, D. (deposition date: 2022-11-29, release date: 2024-02-21, Last modification date: 2024-04-03)

• Primary citation: Tamulaitiene, G.,Sabonis, D.,Sasnauskas, G.,Ruksenaite, A.,Silanskas, A.,Avraham, C.,Ofir, G.,Sorek, R.,Zaremba, M.,Siksnys, V.; Activation of Thoeris antiviral system via SIR2 effector filament assembly.; Nature, 627:431-436, 2024; PubMed: 38383786; DOI: 10.1038/s41586-024-07092-x

Experimental method

ELECTRON MICROSCOPY (2.96 Å)