8BQU

Molecular basis of ZP3/ZP1 heteropolymerization: crystal structure of a native vertebrate egg coat filament

8BQU の概要

• エントリーDOI: 10.2210/pdb8bqu/pdb
• 関連するPDBエントリー: 3NK4 5BUP 5OSQ 6TQK 8RKI
• 分子名称: Zona pellucida sperm-binding protein 3, Choriogenin H, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: cell adhesion, fertilization, egg-sperm interaction, gamete recognition, sperm receptor, extracellular matrix, egg coat, zona pellucida, vitelline envelope, fish chorion, glycoprotein, n-glycan, structural protein, zp module, zp-n domain, zp_c domain, trefoil domain, medaka, japanese rice fish
• 由来する生物種: Oryzias latipes (Japanese medaka); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 72759.76

構造登録者

Bokhove, M.,de Sanctis, D.,Yasumasu, S.,Jovine, L. (登録日: 2022-11-21, 公開日: 2024-03-13, 最終更新日: 2024-03-27)

• 主引用文献: Nishio, S.,Emori, C.,Wiseman, B.,Fahrenkamp, D.,Dioguardi, E.,Zamora-Caballero, S.,Bokhove, M.,Han, L.,Stsiapanava, A.,Algarra, B.,Lu, Y.,Kodani, M.,Bainbridge, R.E.,Komondor, K.M.,Carlson, A.E.,Landreh, M.,de Sanctis, D.,Yasumasu, S.,Ikawa, M.,Jovine, L.; ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat.; Cell, 187:1440-1459.e24, 2024; PubMed: 38490181; DOI: 10.1016/j.cell.2024.02.013

実験手法

X-RAY DIFFRACTION (2.7 Å)