8BN8

METTL3-METTL14 heterodimer bound to the SAM competitive small molecule inhibitor STM3006

This is a non-PDB format compatible entry.

Summary for 8BN8

• Entry DOI: 10.2210/pdb8bn8/pdb
• Descriptor: N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, 2-[[4-(6-bromanyl-2~{H}-indazol-4-yl)-1,2,3-triazol-1-yl]methyl]-6-[(4,4-dimethylpiperidin-1-yl)methyl]imidazo[1,2-a]pyridine, ... (4 entities in total)
• Functional Keywords: methyltransferase, sam, inhibitor, m6a, rna binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 59211.40

Authors

Pilka, E.S.,Thomas, B.,Blackaby, W.,Hardick, D.,Feeney, K.,Ridgill, M.,Rotty, B.,Rausch, O. (deposition date: 2022-11-13, release date: 2023-09-20, Last modification date: 2023-10-18)

• Primary citation: Guirguis, A.A.,Ofir-Rosenfeld, Y.,Knezevic, K.,Blackaby, W.,Hardick, D.,Chan, Y.C.,Motazedian, A.,Gillespie, A.,Vassiliadis, D.,Lam, E.Y.N.,Tran, K.,Andrews, B.,Harbour, M.E.,Vasiliauskaite, L.,Saunders, C.J.,Tsagkogeorga, G.,Azevedo, A.,Obacz, J.,Pilka, E.S.,Carkill, M.,MacPherson, L.,Wainwright, E.N.,Liddicoat, B.,Blyth, B.J.,Albertella, M.R.,Rausch, O.,Dawson, M.A.; Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity.; Cancer Discov, 13:2228-2247, 2023; PubMed: 37548590; DOI: 10.1158/2159-8290.CD-23-0007

Experimental method

X-RAY DIFFRACTION (2.213 Å)