8BK1

Mutant Imine Reductase IR007-143 from Amycolatopsis azurea, E120A, M197W, M206S, A213P, D238G, I240L

Summary for 8BK1

• Entry DOI: 10.2210/pdb8bk1/pdb
• Descriptor: Mutant Imine Reductase IR007-143 from Amycolatopsis azurea, E120A, M197W, M206S, A213P, D238G, I240L, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ... (4 entities in total)
• Functional Keywords: amine, imine nadph, biocatalyst, oxidoreductase
• Biological source: Amycolatopsis azurea
• Total number of polymer chains: 4
• Total formula weight: 127394.46

Authors

Gilio, A.K.,Grogan, G.J. (deposition date: 2022-11-08, release date: 2023-09-20)

• Primary citation: Steflik, J.,Gilio, A.,Burns, M.,Grogan, G.,Kumar, R.,Lewis, R.,Martinez, C.; Engineering of a Reductive Aminase to Enable the Synthesis of a Key Intermediate to a CDK 2/4/6 Inhibitor; Acs Catalysis, 13:10065-10075, 2023; DOI: 10.1021/acscatal.3c01534

Experimental method

X-RAY DIFFRACTION (2.7 Å)