8BIQ

Crystal structure of acyl-COA synthetase from Metallosphaera sedula in complex with acetyl-AMP

Summary for 8BIQ

Entry DOI	10.2210/pdb8biq/pdb
Descriptor	4-hydroxybutyrate--CoA ligase 1, ADENOSINE MONOPHOSPHATE, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] ethanoate (3 entities in total)
Functional Keywords	ligase, coa-ligase, acyl-coa ligase, acetyl-coa ligase, thermostable ligase, thermostable, acetyl-amp, substrate bound, monomer
Biological source	Metallosphaera sedula DSM 5348
Total number of polymer chains	4
Total formula weight	262329.27
Authors	Capra, N.,Thunnissen, A.M.W.H.,Janssen, D.B. (deposition date: 2022-11-02, release date: 2023-11-15, Last modification date: 2024-03-13)
Primary citation	Capra, N.,Lelievre, C.,Toure, O.,Fossey-Jouenne, A.,Vergne-Vaxelaire, C.,Janssen, D.B.,Thunnissen, A.M.W.H.,Zaparucha, A. Adapting an acyl CoA ligase from Metallosphaera sedula for lactam formation by structure-guided protein engineering Front Catal, 4:-, 2024 Cited by DOI: 10.3389/fctls.2024.1360129 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation