8BIN
Crystal structure of human Ephrin type-A receptor 2 (EPHA2) Kinase domain in complex with MR21
Summary for 8BIN
Entry DOI | 10.2210/pdb8bin/pdb |
Descriptor | Ephrin type-A receptor 2, 1,2-ETHANEDIOL, 8-(4-azanylbutyl)-6-(2-chlorophenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one, ... (4 entities in total) |
Functional Keywords | epha2, eck, typ i inhibitor, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 35255.15 |
Authors | Zhubi, R.,Rak, M.,Knapp, S.,Kraemer, A.,Structural Genomics Consortium (SGC) (deposition date: 2022-11-02, release date: 2022-11-23, Last modification date: 2024-01-31) |
Primary citation | Rak, M.,Tesch, R.,Berger, L.M.,Shevchenko, E.,Raab, M.,Tjaden, A.,Zhubi, R.,Balourdas, D.I.,Joerger, A.C.,Poso, A.,Kramer, A.,Elson, L.,Lucic, A.,Kronenberger, T.,Hanke, T.,Strebhardt, K.,Sanhaji, M.,Knapp, S. Shifting the selectivity of pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors towards the salt-inducible kinase (SIK) subfamily. Eur.J.Med.Chem., 254:115347-115347, 2023 Cited by PubMed: 37094449DOI: 10.1016/j.ejmech.2023.115347 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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