8BIK
Crystal structure of human AMPK heterotrimer in complex with allosteric activator C455
Summary for 8BIK
Entry DOI | 10.2210/pdb8bik/pdb |
Descriptor | 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... (7 entities in total) |
Functional Keywords | ampk activator, allosteric activator, adam site, structure-based drug design, selectivity, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 266753.78 |
Authors | Schimpl, M.,Mather, K.M.,Boland, M.L.,Rivers, E.L.,Srivastava, A.,Hemsley, P.,Robinson, J.,Wan, P.T.,Hansen, J.,Read, J.A.,Trevaskis, J.L.,Smith, D.M. (deposition date: 2022-11-02, release date: 2024-05-15, Last modification date: 2024-06-12) |
Primary citation | Mather, K.M.,Boland, M.L.,Rivers, E.L.,Srivastava, A.,Schimpl, M.,Hemsley, P.,Robinson, J.,Wan, P.,Hansen, J.,Read, J.A.,Trevaskis, J.L.,Smith, D.M. Direct beta 1/ beta 2 AMPK activation reduces liver steatosis but not fibrosis in a mouse model of non-alcoholic steatohepatitis Biorxiv, 2024 Cited by DOI: 10.1101/2024.05.30.596624PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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