8BI2
Syk kinase domain in complex with macrocyclic inhibitor 20a
Summary for 8BI2
Entry DOI | 10.2210/pdb8bi2/pdb |
Descriptor | Tyrosine-protein kinase SYK, 10,13,23-trimethyl-16-oxa-2,4,8,9,13,19,23,30-octazapentacyclo[19.5.2.1^{3,7}.1^{8,11}.0^{24,28}]triaconta-1(27),3,5,7(30),9,11(29),21,24(28),25-nonaen-20-one (3 entities in total) |
Functional Keywords | syk kinase transferase inhibitor, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 35341.50 |
Authors | Read, J.A.,Patel, J. (deposition date: 2022-11-01, release date: 2023-06-14, Last modification date: 2024-05-01) |
Primary citation | Grimster, N.P.,Gingipalli, L.,Balazs, A.,Barlaam, B.,Boiko, S.,Boyd, S.,Dry, H.,Goldberg, F.W.,Ikeda, T.,Johnson, T.,Kawatkar, S.,Kemmitt, P.,Lamont, S.,Lorthioir, O.,Mfuh, A.,Patel, J.,Pike, A.,Read, J.,Romero, R.,Sarkar, U.,Sha, L.,Simpson, I.,Song, K.,Su, Q.,Wang, H.,Watson, D.,Wu, A.,Zehnder, T.E.,Zheng, X.,Li, S.,Dong, Z.,Yang, D.,Song, Y.,Wang, P.,Liu, X.,Dowling, J.E.,Edmondson, S.D. Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors. Bioorg.Med.Chem.Lett., 91:129352-129352, 2023 Cited by PubMed: 37270074DOI: 10.1016/j.bmcl.2023.129352 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.508 Å) |
Structure validation
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