8BI2

Syk kinase domain in complex with macrocyclic inhibitor 20a

8BI2 の概要

• エントリーDOI: 10.2210/pdb8bi2/pdb
• 分子名称: Tyrosine-protein kinase SYK, 10,13,23-trimethyl-16-oxa-2,4,8,9,13,19,23,30-octazapentacyclo[19.5.2.1^{3,7}.1^{8,11}.0^{24,28}]triaconta-1(27),3,5,7(30),9,11(29),21,24(28),25-nonaen-20-one (3 entities in total)
• 機能のキーワード: syk kinase transferase inhibitor, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35341.50

構造登録者

Read, J.A.,Patel, J. (登録日: 2022-11-01, 公開日: 2023-06-14, 最終更新日: 2024-05-01)

• 主引用文献: Grimster, N.P.,Gingipalli, L.,Balazs, A.,Barlaam, B.,Boiko, S.,Boyd, S.,Dry, H.,Goldberg, F.W.,Ikeda, T.,Johnson, T.,Kawatkar, S.,Kemmitt, P.,Lamont, S.,Lorthioir, O.,Mfuh, A.,Patel, J.,Pike, A.,Read, J.,Romero, R.,Sarkar, U.,Sha, L.,Simpson, I.,Song, K.,Su, Q.,Wang, H.,Watson, D.,Wu, A.,Zehnder, T.E.,Zheng, X.,Li, S.,Dong, Z.,Yang, D.,Song, Y.,Wang, P.,Liu, X.,Dowling, J.E.,Edmondson, S.D.; Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.; Bioorg.Med.Chem.Lett., 91:129352-129352, 2023; PubMed: 37270074; DOI: 10.1016/j.bmcl.2023.129352

実験手法

X-RAY DIFFRACTION (1.508 Å)