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8BFJ

CNOT11-GGNBP2 complex

8BFJ の概要
エントリーDOI10.2210/pdb8bfj/pdb
分子名称CCR4-NOT transcription complex subunit 11, Gametogenetin-binding protein 2, 1,2-ETHANEDIOL, ... (4 entities in total)
機能のキーワードcnot11-ggnbp2 complex, rna binding protein
由来する生物種Homo sapiens (human)
詳細
タンパク質・核酸の鎖数2
化学式量合計25108.14
構造登録者
Basquin, J.,Ozgur, S.,Conti, E. (登録日: 2022-10-26, 公開日: 2022-12-28, 最終更新日: 2024-06-19)
主引用文献Mauxion, F.,Basquin, J.,Ozgur, S.,Rame, M.,Albrecht, J.,Schafer, I.,Seraphin, B.,Conti, E.
The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions.
Cell Rep, 42:111902-111902, 2023
Cited by
PubMed Abstract: The evolutionary conserved CCR4-NOT complex functions in the cytoplasm as the main mRNA deadenylase in both constitutive mRNA turnover and regulated mRNA decay pathways. The versatility of this complex is underpinned by its modular multi-subunit organization, with distinct structural modules actuating different functions. The structure and function of all modules are known, except for that of the N-terminal module. Using different structural approaches, we obtained high-resolution data revealing the architecture of the human N-terminal module composed of CNOT1, CNOT10, and CNOT11. The structure shows how two helical domains of CNOT1 sandwich CNOT10 and CNOT11, leaving the most conserved domain of CNOT11 protruding into solvent as an antenna. We discovered that GGNBP2, a protein identified as a tumor suppressor and spermatogenic factor, is a conserved interacting partner of the CNOT11 antenna domain. Structural and biochemical analyses thus pinpoint the N-terminal CNOT1-CNOT10-CNOT11 module as a conserved protein-protein interaction platform.
PubMed: 36586408
DOI: 10.1016/j.celrep.2022.111902
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.23 Å)
構造検証レポート
Validation report summary of 8bfj
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-10-30に公開中

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