8BCY
HUMAN PI3KDELTA IN COMPLEX WITH COMPOUND 13
Summary for 8BCY
Entry DOI | 10.2210/pdb8bcy/pdb |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, 9-[2-(3,4-dichlorophenyl)ethyl]-2-(3-hydroxyphenyl)-8-oxidanylidene-7~{H}-purine-6-carboxamide, ... (4 entities in total) |
Functional Keywords | pi3kdelta kinase, pi3kdelta kinase inhibitor, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 137924.46 |
Authors | Pala, D.,Mazzucato, R.,Capelli, A.M.,Rancati, F.,Biagetti, M. (deposition date: 2022-10-17, release date: 2023-05-10, Last modification date: 2024-06-19) |
Primary citation | Mazzucato, R.,Roberti, M.,Capelli, A.M.,Rancati, F.,Biagetti, M.,Fiorelli, C.,Bruno, P.,Ronchi, P.,Bertolini, S.,Corsi, M.,Pala, D. Application of an "inhalation by design" approach to the identification and in-vitro evaluation of novel purine based PI3K delta inhibitors. Eur.J.Med.Chem., 254:115331-115331, 2023 Cited by PubMed: 37094451DOI: 10.1016/j.ejmech.2023.115331 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.43 Å) |
Structure validation
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