8BCY

HUMAN PI3KDELTA IN COMPLEX WITH COMPOUND 13

8BCY の概要

• エントリーDOI: 10.2210/pdb8bcy/pdb
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, 9-[2-(3,4-dichlorophenyl)ethyl]-2-(3-hydroxyphenyl)-8-oxidanylidene-7~{H}-purine-6-carboxamide, ... (4 entities in total)
• 機能のキーワード: pi3kdelta kinase, pi3kdelta kinase inhibitor, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 137924.46

構造登録者

Pala, D.,Mazzucato, R.,Capelli, A.M.,Rancati, F.,Biagetti, M. (登録日: 2022-10-17, 公開日: 2023-05-10)

• 主引用文献: Mazzucato, R.,Roberti, M.,Capelli, A.M.,Rancati, F.,Biagetti, M.,Fiorelli, C.,Bruno, P.,Ronchi, P.,Bertolini, S.,Corsi, M.,Pala, D.; Application of an "inhalation by design" approach to the identification and in-vitro evaluation of novel purine based PI3K delta inhibitors.; Eur.J.Med.Chem., 254:115331-115331, 2023; PubMed: 37094451; DOI: 10.1016/j.ejmech.2023.115331

実験手法

X-RAY DIFFRACTION (2.43 Å)