8BBH

The crystal structure of a mouse Fab fragment TL1 in complex with a human Glucose-6-phosphate isomerase peptide 293-307

8BBH の概要

• エントリーDOI: 10.2210/pdb8bbh/pdb
• 分子名称: Glucose-6-phosphate isomerase, Heavy Chain of TL1 Fab fragment, Light Chain of TL1 Fab fragment, ... (4 entities in total)
• 機能のキーワード: antibody fab fragment, immune system
• 由来する生物種: Mus musculus; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 48744.60

構造登録者

Ge, C.,Holmdahl, R.,Li, T. (登録日: 2022-10-13, 公開日: 2022-12-21, 最終更新日: 2024-10-23)

主引用文献

Li, T.,Ge, C.,Kramer, A.,Sareila, O.,Leu Agelii, M.,Johansson, L.,Forslind, K.,Lonnblom, E.,Yang, M.,Xu, B.,Li, Q.,Cheng, L.,Bergstrom, G.,Fernandez, G.,Kastbom, A.,Rantapaa-Dahlqvist, S.,Gjertsson, I.,Holmdahl, R.
Pathogenic antibody response to glucose-6-phosphate isomerase targets a modified epitope uniquely exposed on joint cartilage.
Ann Rheum Dis, 82:799-808, 2023

PubMed Abstract: To identify the arthritogenic B cell epitopes of glucose-6-phosphate isomerase (GPI) and their association with rheumatoid arthritis (RA).

PubMed: 36858822
DOI: 10.1136/ard-2022-223633

実験手法

X-RAY DIFFRACTION (1.619 Å)