8B98

Crystal structure of the human BRD4-BD1 bromodomain in complex with the inhibitor CRCM5483

Summary for 8B98

• Entry DOI: 10.2210/pdb8b98/pdb
• Descriptor: Bromodomain-containing protein 4, ~{N}-[[4-[[7-ethyl-2,6-bis(oxidanylidene)purin-3-yl]methyl]cyclohexyl]methyl]-3-fluoranyl-4-(oxan-4-yloxy)benzenesulfonamide, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: epigenetic, inhibition, inhibitor, selectivity, complex, bd1, protein binding
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 15927.36

Authors

Carrasco, K.,Betzi, S.,Morelli, X. (deposition date: 2022-10-05, release date: 2024-04-03, Last modification date: 2026-03-04)

• Primary citation: Carrasco, K.,Betzi, S.,Morelli, X.; Crystal structure of the human BRD4-BD1 bromodomain in complex with the inhibitor CRCM5464; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.495 Å)