8B8U
Crystal structure of JAK2 JH2-V617F in complex with HTS-A3
Summary for 8B8U
Entry DOI | 10.2210/pdb8b8u/pdb |
Descriptor | Tyrosine-protein kinase JAK2, GLYCEROL, 3,5-diphenyl-2-(trifluoromethyl)-1~{H}-pyrazolo[1,5-a]pyrimidin-7-one, ... (4 entities in total) |
Functional Keywords | janus kinase, pseudokinase, inhibitor complex, jak2, jh2, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 67509.10 |
Authors | Haikarainen, T.,Silvennoinen, O. (deposition date: 2022-10-05, release date: 2023-02-01, Last modification date: 2024-02-07) |
Primary citation | Virtanen, A.T.,Haikarainen, T.,Sampathkumar, P.,Palmroth, M.,Liukkonen, S.,Liu, J.,Nekhotiaeva, N.,Hubbard, S.R.,Silvennoinen, O. Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain. Pharmaceuticals, 16:-, 2023 Cited by PubMed: 36678572DOI: 10.3390/ph16010075 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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