8B7Y

Cryo-EM structure of the E.coli 70S ribosome in complex with the antibiotic Myxovalargin B.

This is a non-PDB format compatible entry.

Summary for 8B7Y

• Entry DOI: 10.2210/pdb8b7y/pdb
• Related: 7QQ3
• EMDB information: 14121 15905
• Related PRD ID: PRD_002441
• Descriptor: 23S ribosomal RNA, 50S ribosomal protein L16, 50S ribosomal protein L17, ... (57 entities in total)
• Functional Keywords: ribosome, antibiotic, myxovalargin b, myxb, fmet-trna, p-trna
• Biological source: Escherichia coli K-12; More
• Total number of polymer chains: 52
• Total formula weight: 2126168.93

Authors

Koller, T.O.,Graf, M.,Wilson, D.N. (deposition date: 2022-10-03, release date: 2023-01-25, Last modification date: 2023-02-01)

• Primary citation: Koller, T.O.,Scheid, U.,Kosel, T.,Herrmann, J.,Krug, D.,Boshoff, H.I.M.,Beckert, B.,Evans, J.C.,Schlemmer, J.,Sloan, B.,Weiner, D.M.,Via, L.E.,Moosa, A.,Ioerger, T.R.,Graf, M.,Zinshteyn, B.,Abdelshahid, M.,Nguyen, F.,Arenz, S.,Gille, F.,Siebke, M.,Seedorf, T.,Plettenburg, O.,Green, R.,Warnke, A.L.,Ullrich, J.,Warrass, R.,Barry 3rd, C.E.,Warner, D.F.,Mizrahi, V.,Kirschning, A.,Wilson, D.N.,Muller, R.; The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition.; J.Am.Chem.Soc., 145:851-863, 2023; PubMed: 36603206; DOI: 10.1021/jacs.2c08816

Experimental method

ELECTRON MICROSCOPY (3 Å)